Topics: Dose-Response Relationship, Pharmacokinetics, Pharmacodynamics, drug absoprtion, drug distribution, Drug Elimination, Pharmacokinetic Principles, Nervous System, Peripheral Efferent Nervous System, Parasympathomimetic Drugs, Anticbolinergic Drugs, Sympathomimetic Drugs, Adrenergic Receptor Antagonists, diuretics, Antidiuretic Drugs, Antihypertensive Drugs, Congestive Heart Failure, Antianginal Agents, Anti.anhythmic Drugs, Sedative-Hypnotic Drugs, Antipsychotic Drugs, Neuroleptic Drugs, Antidepressant Drugs, Anticonvulsants, Parkinson Disease, Alzheimer Disease, Antiepileptic Drugs, Anesthetics, Opioid Analgesics, Antagonists, AUTOCOIDS, ERGOTS, ANTI-INFLAMMATORY AGENTS, IMMUNOSUPPRESSIVE AGENTS, Histamine, Antihistamine, Serotonin Agonists, Serotonin Antagonists, Ergot Alkaloids, Eicosanoids, Salicylates and Nonsteroidal Anti-inflammatory Drugs, NSAIDs, Immunosuppressive Drugs, Hemostatic Disorder, anaemia, Antiemetics, obesity, Infectious Disease Therapy, Antibacterial Agents, Antimycobacterial Agents, Antifungal Agents, Antiparasitic Drugs, Antiviral Drugs, Antiretroviral Drugs, Cancer Chemotherapy, Alkylating Agents, Antimetabolites, Microtubule Damaging Agents, Topoisomerase Inhibitors, Antitumor Antibiotics, Antineoplastic Agents, Corticosteroids, Hormone Therapy, TOXICOLOGY, Insecticides, Herbicides, Heavy Metal Poisoning, solvents