Pharmacology of Anemia by Haas Jimoh Akanbi PDF free download

Topics: Immune Hemolytic disorder, Auto-immune Hemolytic anemia, Cold AIHA, Paroxysmal Cold hemoglobinuria, Allo-immune Hemolytic anemia, immune Thrombocytopenic purpura, Evan's syndrome, IMMUNE HEMOLYTIC ANEMIA, Antibody-mediated hemolysis, AUTOIMMUNE HEMOLYTIC ANEMIA, Red cell destruction, cold AIHA syndrome, warm AIHA, ALLOIMMUNE HEMOLYTIC ANEMIA, DRUG-INDUCED HEMOLYTIC ANEMIA, ACQUIRED NON-IMMUNE HEMOLYTIC ANEMIA, INTRAVASCULAR HEMOLYSIS, BLACK WATER FEVER, HEMOPHAGOCYTIC SYNDROME, FRAGMENTATION HEMOLYSIS, MECHANICAL HEMOLYTIC ANEMIA, RED CELL FRAGMENTATION SYNDROME, MICROANGIOPATHIC HEMOLYTIC ANEMIA, HEMOLYTIC UREMIC SYNDROME, THROMBOTIC THROMBOCYTOPENIC PURPURA

Topics: Eukaryotic cell, cell, Carbohydrates, Monosaccharides, glucose, Disaccharides, Polysaccharides, Homopolysaccharides, Heteropolysaccharides, Agar, pectin, Glycoproteins, Lipids, Fatty acids, Essential fatty acids.Phospholipids, Glycolipids, Lipoproteins, Steroids, Amphipathic lipids, Soaps, detergents, Proteins, Amino Acids, Nucleic Acids, Nucleotides, Enzymes, DNA, RNA, enzyme activity, Active site, Enzyme inhibition, Enzyme specificity, Coenzymes, enzyme action, Non-protein enzymes, Isoenzymes, Vitamins, Vitamin A, Vitamin D, Vitamin E, Vitamin K, Vitamin C, Ascorbic acid, Thiamine, Vitamin B1, Riboflavin, Vitamin B2, Niacin, Pyridoxine, Vitamin B6, Biotin, Pantothenic acid, Folic acid, Cobalamin, Vitamin B12, Choline, Inositol, Lipoic acid, Para aminobenzoic acid, Bioflavonoids, Antivitamins, Physiological Biochemistry, Digestion, Absorption, Plasma Proteins, Albumin, Globulins, Immunoglobulins, Blood clotting, Hemoglobin, Porphyrins, Hemoglobin derivatives, Abnormal hemoglobins, Sickle-cell anemia, sickle-cell hemoglobin, Thalassemias, Porphyrias, Jaundice, Biological Oxidation, Bioenergetics, High-energy compounds, Electron transport chain, Oxidative phosphorylation, Metabolism, Glycolysis, Citric acid cycle, Gluconeogenesis, Glycogen metabolism, Glycogen storage diseases, Hexose monophosphate shunt, Uronic acid pathway, Glyoxylate cycle, Fatty acid oxidation, Ketone bodies, Fatty liver, obesity, Atherosclerosis, Alcohol metabolism, Amino acid pool, Urea cycle, Glycine, Phenylalanine, tyrosine, Tryptophan, Sulfur amino acids, One-carbon metabolism, Histidine, proline, arginine, Lysine, Glutamate, glutamine, Aspartate, asparagine, Serine, Threonine, Biogenic amines, Polyamines, purine, Mineral Metabolism, Nutrition, Hormones, Organ Function Tests, water, Tissue Proteins, Body Fluids, Molecular Biology, Biotechnology, DNA-Replication, Transcription, Translation, Gene Expression, Recombinant DNA, Human Genome Project, Gene Therapy, Bioinformatics, Xenobiotics, Detoxification, Prostaglandins, Free Radicals, Antioxidants, Environmental Biochemistry, Insulin, cancer, Acquired Immunodeficiency Syndrome

Topics: Cobalamin, Vitamin B12, Vitamin B12 deficiency, folic acid, Vitamin C, Vitamin C deficiency, scurvy

Topics: Gene Transcription, Messenger RNA, DNA Mutation, gene expression, Lineage Commitment, Micro-RNAs, Regulatory Noncoding RNAs, DNA Replication, Telomeres, Cell Cycle, Apoptosis, Cellular Debris, Lysosomes, Protein Ubiquitination,  Clonal Hematologic Disorders, Erythropoiesis, Bone Marrow, Peripheral Blood, Hypochromic Microcytic Anemias, Iron Metabolism, Iron Absorption, Hepcidin, Iron Homeostasis, Iron‐Deficiency Anemia, Hypochromic Anemias, Sideroblastic Anemia, Lead Poisoning, alchohol, Lead Poisoning, Hematopoiesis, Hematopoietic Niche, growth factor signaling, Congenital Erythropoietic Porphyria, Congenital Erythropoietic Protoporphyria, iron overload, porphyrias, megoblastic anemia, Bone Marrow Appearances, Phagocytic Function, Leukocytosis, Leukoerythroblastic Reaction, Neutropenia, Myelokathexis, Lysosomal Storage Diseases, Hereditary Hemolytic Anemia, Hemolytic Anemia, Acquired Hemolytic Anemia, genetic disorders, Thalassemia, α‐Thalassemia, T Cells, B cells, Natural Killer Cells, Lymphocyte Proliferation, Somatic Hypermutation, Lymphocyte Circulation, Lymphocytosis, Lymphadenopathy, Primary Immunodeficiency Disorders, Granulopoiesis, Monocyte Production, Neutrophils, Polymorphs, Mononuclear Phagocytic System, Reticuloendothelial System, Autoimmune Lymphoproliferative Syndrome, Acquired Immunodeficiency Syndrome, Aplastic Anemia, Red Cell Aplasia, Congenital Dyserythropoietic Anemias, MYELODYSPLASTIC SYNDROMES, molecular genetics, Mirage Syndrome, Clonal Hematopoiesis, HEMATOLOGIC NEOPLASMS, MYELOID LEUKEMIA, Acute Myeloid Leukemia, MYELOPROLIFERATIVE NEOPLASMS, Chronic Myeloid Leukemia, Chronic Neutrophilic Leukemia, Nonleukemic Myeloproliferative Diseases, Polycythemia Vera, Myelofibrosis, Chronic Eosinophilic Leukemia, Myeloproliferative Disorder, ACUTE LYMPHOBLASTIC LEUKEMIA, Mastocytosis, Paraneoplastic Pemphigus, Myeloid Neoplasm, Lymphoid Neoplasm, Myelodysplastic Neoplasm, Myeloproliferative Neoplasm, Ring Sideroblast, Thrombocytosis, Juvenile Myelomonocytic Leukemia, CHRONIC LYMPHOCYTIC LEUKEMIA, Mature B‐Cell Leukemia, Mature T‐C

Topics: Hemostasis, Blood Component Therapy, Cellular Homeostasis, Cell Morphology, cell membrane, cytoplasm, nucleus, DNA duplication, DNA transcription, DNA translation, Gene expression, Protein Synthesis, Protein Processing, Ubiquitin System, Ubiquitin System, Apoptosis, cell cycle, Abnormal Tissue Homeostasis, cancer, Hematopoietic System, Hematopoietic Organs, Hematopoiesis, Hematopoietic Tissue, bone marrow, thymus, spleen, lymph nodes, Mucosa-Associated Lymphoid Tissue, Lymphadenopathy, Hematopoietic Precursor Cells, Growth Factor Function, cytokine, growth factor, Cytokine Receptors, Signaling Pathways, transcription Factors, Hematopoietic Growth Factors, Hematopoietic Microenvironment, Hemoglobin Structure, Hemoglobin, Hemoglobin Synthesis, heme, Globin Chain Synthesis, Embryonic Hemoglobins, Fetal Hemoglobin, Adult Hemoglobins, Glycosylated Hemoglobin, Hemoglobin Function, Oxygen Transport, Carbon Dioxide Transport, Artificial Oxygen Carriers, Hemoglobin Catabolism, Extravascular Destruction, Intravascular Destruction, Acquired Nonfunctional Hemoglobins, Methemoglobin, Sulfhemoglobin, Carboxyhemoglobin, Erythropoiesis, Red Blood Cell Maturation, Erythroid Progenitor Cells, Erythroid-Maturing Cells, cell maturation, Erythroblastic Islands, Erythrocyte, Erythrocyte Membrane, Membrane Permeability, Erythrocyte Metabolism, Glycolytic Pathway, Hexose Monophosphate shunt, Methemoglobin Reductase Pathway, Rapoport-Luebering Shunt, Erythrocyte Kinetics, Erythrocyte Concentration, Granulocyte, Monocyte, Leukocyte Surface Markers, Leukocyte Function, neutrophils, Eosinophils, Basophils, Lymphocyte Function, Lymphocyte Metabolism, aging, platelet, lymphocytes, complete blood count, peripheral blood smear evaluation, anaemia, Hemoglobinopathies, heme synthesis, megoblastic anaemia, Thalassemia, Hypoproliferative Anemia, Hemolytic Anemia, immune anemia, Lymphocyte Disorders, Myeloproliferative Neoplasms, Neoplastic Hematologic Disorders, Hematopoietic Neoplasms, Myelodysplastic Syndromes, Acute Myeloid Leukemia, Precursor Lymphoid Neoplasm, Bone Marrow, Thrombophilia

Topics: CELLULAR INJURY, ACUTE INFLAMMATION, Inflammation, Tissue Repair, wound healing, regeneration, healing, Circulatory Pathology, edema, Genetic Disorders, Immunopathology, hypersensitivity reactions, Amyloidosis, amyloid, neoplasia, carcinogenic agents, carcinogenesis, cancer, Skin Pathology, pigmentation, melanocytic tumors, epidermal lesions, dermal lesions, malignant tumors, Red Blood Cell Pathology, Anemia, red blood cell morphology, microcytic anemia, normocytic anemia, macrocytic anemia, polycythemia vera, Vascular Pathology, vasculitides, Raynaud disease, arteriosclerosis, hypertension, aneurysm, arteriovenous fistula, venous disease, vascular neoplasms, Cardiac Pathology, ISCHEMIC HEART DISEASE, Respiratory Pathology, congenital cystic lung lesions, atelectasis, pulmonary infections, sarcoidosis, obstructive versus restrictive lung disease, pulmonary neoplasia, laryngeal neoplasia, pleural cavity, Renal Pathology, nephritic syndrome, nephrotic syndrome, secondary glomerulonephritis, chronic glomerulonephritis, tubulointerstitial nephritis, acute tubular injury, urolithiasis, chronic renal failure, ureteral disorders, urinary bladder pathology, Gastrointestinal Tract Pathology, gastric lymphoma, Pancreatic Pathology, Gallbladder Pathology, Biliary Tract Pathology, Liver Pathology, jaundice, cirrhosis, viral hepatitis, amebic liver abscess, alcoholic liver disease, hemodynamic liver disease, liver tumors, Central Nervous System Pathology, blood brain barrier, cerebrovascular disease, CNS trauma, brain herniation, perinatal brain injury, demyelinating disorders, degenerative disorders, dementing disorders, CNS tumors, Hematopoetic Pathology, White Blood Cell Disorders, Lymphoid Neoplasms, Myeloid Neoplasms, mature B-cell neoplasm, peripheral T-cell neoplasm, natural killer cell neoplasm, Hodgkin lymphoma, acute leukemia, B and T lymphoblastic lymphoma, T lymphoblastic leukemia, B lymphoblastic leukemia, mast cell diseases, Female Genital Pathology, Breast Pathology, mastitis, gynecomastia, Male Pathology, testicular cancer, prostate disease, prostate disease

Topics: Child Health Disparities, child health, Global Child Health, Pediatric Care, Neonatal Ethics, Newborn Screening, Genetics, Genomics, Precision Medicine, Adolescent Healthcare, Pediatric Ethics, Pediatric Palliative Care.Domestic Adoption, Intercountry Adoption, Foster care, Kinship Care, immunization, Injury Control, childhood injuries, School Violence, Child Temperament, Child Behavioral Problems, Positive Parenting, Pediatrician, Fetal Growth, fetal Development, Neurologic Development, Middle Childhood, Sleep Medicine, chronobiology, Behavioral Disorder, Psychiatric Disorder, Psychiatric Diagnostic Evaluation, Psychopharmacology, ADHD Medications, Antidepressants, Antipsychotics, Mood Stabilizers, Psychotherapy, Psychiatric Hospitalization, Somatic Symptom, Rumination, Pica, Motor Disorders, Habits, Anxiety Disorders, Mood Disorders, Suicide, Attempted Suicide, eating disorder, Disruptive Disorder, Impulse-Control Disorder, Conduct Disorder, Tantrums, Breath-Holding Spells, Lying, Stealing, Truancy, Aggression, Self-Injurious Behavior, Neurodevelopmental Dysfunction, Executive Function Dysfunction, Attention-Deficit, Hyperactivity Disorder, Dyslexia, Math Learning Disability, Impaired Writing, language disorder, communication disorder, Normal Language Development, Motor Speech Disorder, Hearing Impairment, Hydrocephalus, Language Impairment, Language Delay, Autism Spectrum Disorder, Nutrition, Nutritional Requirements, Dietary Reference Intakes, Soy FormulasProtein Hydrolysate Formulas, Complementary Feeding, Feeding Toddlers, Food Security, Malnutrition, Undernutrition, Severe Acute Malnutrition, Refeeding Syndrome, Malnutrition, Overweight, Obesity, Vitamin A Deficiency, Hypervitaminosis A, Thiamine Deficiency, Thiamine Toxicity, Riboflavin Deficiency, Riboflavin Toxicity, Niacin Deficiency, Niacin Toxicity, Vitamin B6 Deficiency, Vitamin B6 Toxicity, Folate Deficiency, Folate Toxicity, Vitamin B12 Deficiency, Vitamin C Deficiency, Vitamin C Toxicity, Ricket, Vitamin D Disorder, Calcium Deficiency, Phosphorus Deficiency, Distal Renal Tubular Acidosis, Hypervitaminosis

Topics: vaccine opposition, vaccine Hesitancy, precision medicine, clinical care, disease prevention, Diagnosis, Palliative care, End-of-life care, pain, chest discomfort, abdominal pain, headache, back pain, neck pain, Fever, Rash, Nervous System Dysfunction, syncope, dizziness, vertigo, fatigue, numbness, tingling, sensory loss, Gait disorders, confusion, Dementia, Aphasia, memory loss, sleep disorders, eye disorder, smell disorder, hearing disorder, dyspnea, cough, hemoptysis, hypoxia, cyanosis, Edema, Palpitations, Dysphagia, Nausea, vomiting, indigestion, Diarrhea, constipation, unintentional weight loss, gastrointestinal bleeding, Jaundice, abdominal swelling, interstitial cystitis, bladder pain syndrome, Azotemia, urinary abnormalities, fluid disturbances, electrolyte disturbances, hypercalcemia, hypocalcemia, acidosis, alkalosis, Eczema, Psoriasis, cutaneous infections, acne, skin disorders, Immunologically Mediated Skin Diseases, Cutaneous Drug Reactions, Photosensitivity, interpreting Peripheral Blood Smears, anemia, Polycythemia, bleeding, thrombosis, pharmacology, Pharmacogenomics, oncology, hematology, neoplastic disorders, cancer genetics, cancer cell biology, cancer treatment, skin cancer, head cancer, neck cancer, breast cancer, upper gastrointestinal tract cancer, lower gastrointestinal cancer, pancreatic cancer, Gastrointestinal Neuroendocrine Tumors, Renal Cell Carcinoma, testicular cancer, Gynecologic Malignancies, Paraneoplastic Syndromes, Paraneoplastic Neurologic Syndromes, Autoimmune Encephalitis, Hematopoietic Disorders, Hematopoietic Stem Cells, Iron deficiency, hemoglobin disorders, Megaloblastic Anemias, Hemolytic Anemias, bone marrow failure syndrome, Polycythemia Vera, Myeloproliferative Neoplasms, Myeloid Leukemia, Acute Lymphoid Leukemia, Chronic Lymphocytic Leukemia, plasma cell disorders, Amyloidosis, transfusion therapy, Hematopoietic Cell Transplantation, Coagulation Disorders, hemostasis disorders, Antiplatelet Drugs, Anticoagulant Drugs, Fibrinolytic Drugs, infectious disease, microbial genomics, Pneumonia, clinical syndromes, community-acquired infections, lung abscess, infective endocarditis, Infectious Arthritis, Osteomyelitis, Intraabdominal Infections, Intraabdominal Abscesses, Acute Infectious Diarrheal Diseases, Bacterial Food Poisoning, Clostridioides difficile Infection, Pseudomembranous Colitis, Urinary Tract Infections, Pyelonephritis, Prostatitis, Sexually Transmitted Infections, Encephalitis, Acute Meningitis, Brain Abscess, Pneumococcal Infections, Staphylococcal Infections, Streptococcal Infections, Enterococcal Infections, Listeria monocytogenes Infections, Tetanus

Topics: Blood, Physiology, red blood cell morphology, red blood cell, Erythropoiesis, Poikilocytosis, Anisocytosis, Roleaux, Pluripotential haemopoietic stem cells, Colony Forming Unit erythrocyte, Erythropoietin, folic acid, iron, Pluripotential haemopoietic stem cells, Blood transfusion, anaemia, platelets, thrombocytes, white blood cell, Neutrophils, Cortisol hormone, eosinophils, Basophils, Lymphocytes, Monocyte, reticulocyte, myelopoiesis, Chemotaxis, Opsonization, Diapedesis, Phagocytosis, Leukaemia, Leukopenia, blood group, Rhesus factor, Agglutinin, blood fluid compartments, Agglutinin, intracellular fluid, Hyponatraemia, Hypernatraemia, Hypokalaemia, biological rhythm, Transmembrane protein, membrane transport, passive transport, active transport, haemoglobin level, haemoglobin disease, anemia, biological potentials, resting membrane potential, action potential, cell, osmolality, nerve impulse conduction, synaptic transmission, neuromuscular transmission, neurotransmitters

Topics: Hematopoietic Stem Cell Transplantation, Stem cell transplantation, Autologous Hematopoietic Stem Cell Transplantation, synthetic Hematopoietic Stem Cell Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation, Peripheral Blood Stem Cell Transplantation, Peripheral Blood Stem Cell Harvest, bone marrow harvest, Umbilical Cord Blood Hematopoietic Stem Cell Transplantation, Marrow Donor search, Core Family Donor Search, Extended Family Donor Search, Unrelated Donor Search, Bone Marrow Registry

Topics: Bilirubin Metabolism, Fetal Bilirubin Metabolism, Jaundice, bilirubin excretion, Antibody mediated haemolysis, Red Cell, Red Cell Enzyme defects, Red Cell Membrane defects, ABO Incompatibility, Rh Incompatibility, anti-E & c, anti- Kell, Minor blood group incompatibility, G-6-P-D deficiency, Pyruvate kinase deficiency, Hereditary spherocytosis, Elliptocytosis, EXTRAVASCULAR BLOOD, DRUG INDUCED HEMOLYSIS, Vitamin K3 induced haemolysis, POLYCYTHAEMIA, glucoronosyl transferase, Galactosaemia, Exchange Blood Transfusion, Phototherapy, Chronic Postkernicteric Encephalopathy, Bilirubin Encephalopathy, Bilirubin Toxicity, Encephalopathy, Breast Milk Jaundice, G6PD Deficiency, Iso-immune Haemolytic Diseases

Topics: Body Fluid, Blood Physiology, plasma, red blood cells, Erythropoiesis, Proerythroblast, Basophil erythroblast, Polychromatophil Erythroblast, Reticulocyte, Matured Erythrocyte, Hemoglobin, anemia, Hemorrhagic Anemia, Hemolytic Anemia, Thalassemia, Nutrition Deficiency Anemia, Pernicious anemia, Megaloblastic anemia, Aplastic Anemia, Idiopathic Anemia, Polycythemia, white blood cells, Neutrophils, Eosinophils, basophils, immunity, antibodies, antigens, Antigen-Presenting Cells, Passive Immunity, Passive Natural Immunization, hypersensitivity, allergy, blood groups, hemostasis, Platelets

Topics: SINUSITIS, audiology, PEDIATRIC OTOLARYNGOLOGY, HEARING LOSS, dysphagia, deep neck space infection, hoarsness, vertigo, tinnitus, otalgia, salivary glands, facial nerve paralysis, nasal obstruction, neck masses, epistaxis, neoplasm, carcinoma, Acute Suppurative Sinusitis, Chronic Sinusitis, Acute Otitis Media, Otitis Media, Adenoid Hypertrophy, Acute Tonsillitis, Tonsillectomy, Airway Obstruction, Acute Laryngotracheobroncheitis, Acute Epiglottitis, Subglottic Stenosis, Laryngomalacia, Surgical Airway Management, Peritonsillar Abscess, Quinsy, Retropharyngeal Abscess, Ludwig’s Angina, Acute Tonsillitis, Acute Laryngitis, Chronic Laryngitis, Laryngitis, Vocal Cord Nodules, Vocal Cord Polyps, Benign Laryngeal Papillomas, Laryngeal Carcinoma, Sialadenitis, Sialolithiasis, Congenital Neck Masses, Hypopharynx, Larynx, Nasopharynx, Oropharynx, ear, nose, Pure Tone Audiometry, Speech Audiometry, Impedance Audiometry, Auditory Brainstem Response, Tuning Fork Tests, Otitis Externa, Cholesteatoma, Otosclerosis, Congenital Sensorineural Hearing Loss, Presbycusis, Sudden Sensorineural Hearing Loss, Drug Ototoxicity, Noise-Induced Sensorineural Hearing Loss, Acoustic Neuroma, Temporal Bone Fractures, Aural Rehabilitation, Otoneurological Examination, Bell’s Palsy, Acute Rhinitis, Allergic Rhinitis, Vasomotor Rhinitis, Adenoid Hypertrophy, Nasal Polyps, Septal Deviation, Septal Hematoma, Septal Perforation

Topics: Vitamin B12, Cobalamin, Protein- Bound B12, Folate

Topics: ERYTHROCYTES (RBCS), Erythropoietin, Chronic- GI lesions, Thalassemia, erythroblastosis fetalis, microangiopathic hemolytic anaemia, Sequestration in mononuclear phagocytic system, hyperslenism, hypochromic and normochromic, microcytic, normocytic, macrocytic

Topics: Transient erythoblastopenia, Aplastic anaemia, MEGALOBLASTIC ANAEMIA, IRON DEFICIENCY ANAEMIA, MICROCYTIC ANAEMIA, HAEMOLYTIC ANAEMIA, blood, blood products, RED CELL CONCENTRATE, LEUCOCYTE REDUCED CELLS, DEPLETED RED CELLS, WASHED RED CELLS, red cell synthesis, Recombinat human erythropoietin, Haematinics

Topics: VITAMIN B12 METABOLISM, COBALAMIN MALABSORPTION, Pernicious anaemia, MEGALOBLASTIC ANAEMIA, MACROCYTES, HYPERSEGMENTED NEUTROPHIL, cobalamin deficiency

Topics: Hypochromic Anaemia, Hypochromic Microcytic Anaemia, Hypochromic, Microcytosis, Microcytic anaemia, Iron metabolism, body iron, iron transport, transferrin, lactoferrin, iron storage, Haemosiderin, iron deficiency, iron deficiency anaemia, Bone marrow test, oral iron therapy, Acute iron poisoning, Parenteral iron therapy, iron therapy

Topics: Complete blood count, Hemoglobin, Total Red Blood Cell Count, Hematocrit, spun hematocrit, Centrifuged blood, Mean Corpuscular Volume, Red Cell Distribution Histogram, Red Blood Cell Distribution Width, Red Blood Cell Distribution, White Blood Cell Count, White Blood Cell differential, Platelet Count, Basic Metabolic Panel, sodium, Potassium, calcium, Chloride, Creatinine, Complete Metabolic Panel, Metabolic Panel, Albumin, Alkaline Phosphatase, Aspartate Aminotransferase

Topics: ATHEROGENESIS, Endothelial dysfunction, Smooth muscle cell dysfunction, Architectural disruption, LIPOPROTEIN PARTICLES, Primary chylomicronemia, Primary hypertriglyceridemias, Familial hypertriglyceridemia, Familial combined hyperlipoproteinemia, familial dysbetalipoproteinemia, Primary hypercholesterolemias, Familial hypercholesterolemia, Familial ligand-defective Apolipoprotein B, Familial combined hyperlipoproteinemia, hyperlipoproteinemia, Hypercholesterolemias, Hypertriglyceridemias, REDUCTASE INHIBITORS, STATINS, FIBRATES, Fibric acid derivatives, BILE ACID-BINDING RESINS, NICOTINIC ACID, NIACIN, INTESTINAL STEROL ABSORPTION, EZETIMIBE, COMBINATION THERAPY