Drug development by Shu Elvis PDF free download

Topics: Drug Sources, Drug Benefit Assessment, Congeneric Drugs, Drug Administration, Oral Dosage Forms, dermatological agents, drug distribution, Drug Action, membrance permeation, drug transporters, drug elimination, drug metabolism, enteroheptaic circulation, presystemic elimination, pharmacokinetics, druig concentration, accumulation, dose-response relationship, drug-receptor interaction, agonists-antagonists, enantioselectivity, G-protein-couples receptors, plasma concentration, adverse drug effects, drug allergy, cutaenous reactions, pregnancy, lactation, drug-independent effects, cutaneous reaction, placebo theraphy, systems pharmacology, sympathetic system, cathecholamine actions, sympathomimetics, indirect sympathomimetics, Parasympathetic Nervous System, Parasympathetic Functions, Cholinergic Synapse, Parasympathomimetics, Parasympatholytics, biogenic agents, dopamine, histamine, serotonin, amino acids, vasodilators, organic nitrates, calcium antagonists, Renin-Angiotensin-Aldosterone System, ACE Inhibitors, smooth muscle, cardiac Drugs, Cardiac Glycosides, antiarrhythmic drugs, antianemic agents, anemias, iron compounds, antithrombotic agents, thrombosis therapy, Vitamin K, Heparin, fibrinolytics, platelet aggregation, plasma volume expanders, hyperlipoproteinemias, lipid-lowering agents, diuretics, water reabsorption, vasopressin, water and electrolyte disorders, Gastrointestinal Tract, Hyperacidity, antidiarrheal agents, motor system, muscle relaxants, nociceptors, pain, analgesics, eicosanoids, antipyretic analgesics, local anesthetics, opioids, General Anesthesia and General Anesthetic Drugs.lnhalational Anesthetics, Injectable Anesthetics, Anxiolytics, benzodiazepines, depressive illness, manic state, schizophrenia, endocrine system, hypothalamic hormone, hypophyseal hormone, thyroid hormone therapy, hyperthroidism, antithyroid drugs, glucocorticoid therapy, androgen, anabolic steroid, antiandrogen, follicular growth, ovulation, antibacterial drugs, antifungal drugs, antiviral drugs, antiparasitic drugs, tropical diseases, anticancer drugs, immune modulators

Topics: Drug-nutrient interaction, Food-drug interaction, Pharmacokinetics, Pharmacodynamics, Absorption, ISONIAZID, PHENELZINE, GLUCOSE-6-PHOSPHATE DEHYDROGENASE ENZYME DEFICIENCY, Warfarin, Drug Induced Nutritional Deficiencies

Topics: drug administration, pharmacokinetics, membrane trnasport, distribution of drugs, kinetics of elimination, receptor pharmacology, drug development, clinical pharmacology, adverse drug effects, autonomic nervous system, cholinergic transmission, cholinergic drugs, anticholinergic drugs, autonomic ganglia, adrenergic transmission, adrenergic drugs, antiadrenergic drugs, adrenergic receptor antagonists, glaucoma, autacoids, histamine, antihistaminics, 5-hydroxytryptamine, migraine, prostaglandins, leukotrienes, eicosanoids, platelet activating factor, nonsteroidal antiinflammatory drugs, antipyretic-analgesics, antirheumatoid drugs, antigout drugs, respiratory system drugs, cough, bronchial asthma, hormones, anterior pituitary hormones, thyroid hormones, thyroid inhibitors, insulin, oral antidiabetic drugs, glucagon, corticosteroid, androgen, erectile dysfunction, estrogen, progestin, contraceptives, oxytocin, calcium balance, skeletal muscle relaxants, peripheral nervous system, somatic nervous system, local anaesthetics, central nervous system, general anaesthetics, ethyl, methyl, sedative-hypnotics, antiepileptic drugs, antiparkinsonian drugs, mental illness, antipsychotic, antimanic, antidepressant, antianxiety, Opioid analgesiscs, antagonists, CNS stimulants, cognition enhancers, cardiovascular drugs, cardiac electrophysiological considerations, renin-angiotensin system, nitric oxide, vasoactive peptide signal molecules, cardiac glycoside, heart failure, antiarrhythmic drugs, antianginal drugs, anti-ischaemic drugs, antihypertensive drugs, diuretics, urine formation, antidiuretics, blood formation, haematinics, erythropoietin, hypolipidaemic drugs, peptic ulcer, gastroesophageal reflux disease, antiemetic drugs, prokinetic drugs, digestant drugs, constipation, diarrhoea, antimicrobial drugs, sulfonamides, beta-lactam antibiotics, tetracycline, chloramphenicol, broad spectrum antibiotics, aminoglycoside antibiotics, macrolide, lincosamide, glycopeptide, antibacterial antibiotics, urinary antiseptics, antitubercular, antileprotic drugs, antifungal, antiviral, anticancer

Topics: Pharmacogenomics, Pharmacoepidemiology, DRUG SPECIFICITY, receptor classification, drug concentration, drug effect, spare receptors, COMPETITIVE ANTAGONISM, Irreversible Competitive Antagonism, Partial Agonists, Constitutive Receptor Activation, Inverse Agonists, two-state receptor model, Biased Agonism, Allosteric Modulation, Chemical Antagonism, Pharmacokinetic Antagonism, Receptor–Response Linkage, Physiological Antagonism, Desensitisation, Tolerance, Altered Drug Metabolism, Binding Reaction, Drug–Receptor Interactions, Receptor mechanisms, Ion Channels, Enzymes, Receptor Proteins, Receptor Heterogeneity, Ligand-Gated Ion Channels, Gating Mechanism, G Protein–Coupled Receptors, Proteinase-Activated Receptors, G proteins, phospholipase C, inositol phosphate system, Inositol phosphates, intracellular calcium, Diacylglycerol, protein kinase, MAP kinase system, GPCR desensitisation, Biopharmaceuticals, Chemical Mediators, Presynaptic Modulation, Postsynaptic Modulation, Cholinergic transmission, Nicotinic Receptors, Acetylcholine, Muscarinic Agonists, Muscarinic Antagonists, Ganglion Stimulants, Ganglion-Blocking Drugs, Neuromuscular-Blocking Drugs, Non-Depolarising Blocking Agents, Depolarising Blocking Agents, Cholinesterase Reactivation, Noradrenergic transmission, Adrenoceptor Agonists, α-Adrenoceptor antagonists, 5-Hydroxytryptamine, migraine, Adenosine, purine, Histamine, local hormone, Eicosanoids, Prostanoids, Leukotrienes, Platelet-Activating Factor, Bradykinin, peptide, Neuropeptides, Cytokine, Interferon, Cannabinoids, Endocannabinoids, Nitric oxide, Ischaemic Heart Disease, Antidysrhythmic Drugs, Myocardial Contraction, Anti-Anginal Drugs, Organic Nitrates, Calcium Antagonists, Endothelin, Vasoactive Drugs, Vasodilator Drugs, heart failure, Atherosclerosis, lipoprotein metabolism, Lipoprotein Transport, Lipid-Lowering Drugs, Fibrates, Haemostasis and thrombosis, Blood Coagulation, Warfarin, Platelet Adhesion, Platelet Activation, Antiplatelet Drugs, Adenosine Receptor Antagonists, Fibrinolysis, Thrombolysis, Fibrinolytic Drugs

Topics: ANTIBIOTIC RESISTANCE, INACTIVATION OF ENZYMES, DRUG BINDING, DRUG SENSITIVE SITE, MULTI DRUG RESISTANCE

Topics: drug dependence, psychoactive drug, psychotropic substance, CNS stimulants, xanthine, cocaine, Ephedrine, Benzodiazepines, sedatives, hallucinogens, KETAMINE, PHENCYCLIDINE, cannabinoids, Recreational drugs, inhalant

Topics: Pharmaceutic interaction, Pharmacodynamic interaction, Pharmacokinetic interaction, SYNERGISM, ANTAGONISM, PLASMA PROTEINS, Plasma albumin, DRUG FOOD INTERACTION, DRUG DISEASE INTERACTION

Topics: Drug Therapy, Pharmacokinetics, Drug–Receptor Interactions, Pharmacodynamics, Autonomic Nervous System, Cholinergic Agonists, Cholinergic Antagonists, Adrenergic Agonists, Adrenergic Antagonists, Neurodegenerative Diseases, Anxiolytic drugs, Hypnotic Drugs, Antidepressants, Antipsychotic Drugs, Anesthetics, Opioids, CNS Stimulants, Antihypertensives, diuretics, Heart Failure, epilepsy, Antiarrhythmics, Antianginal Drugs, Anticoagulants, Antiplatelet Agents, Hyperlipidemia, Endocrine System, Pituitary, Thyroid, diabetes, estrogen, androgen, adrenal hormone, bone metabolism, Chemotherapeutic Drugs, Antimicrobial Therapy, Cell Wall Inhibitors, Protein Synthesis Inhibitors, Quinolones, Folic Acid Antagonists, Urinary Tract Antiseptics, Antimycobacterial Drugs, Antifungal Drugs, Antiviral Drugs, Anticancer Drugs, Immunosuppressants, Histamine, Serotonin, Anti-inflammatory Agents, Antipyretic Agents, Analgesic Agents, Gastrointestinal drugs, Antiemetic Drugs, Urologic Disorders, anemia, Dermatologic Disorders, Clinical Toxicology, drugs of abuse, Antiprotozoal Drugs, Anthelmintic Drugs

Topics: drug action, drug absoprtion, drug distribution, drug biotransformation, microsomal enzymes, drug excretion, prolongation of drug action, drug intolerance, drug hypersensitivity, chemical transmitters, 1-Acetylcholine, muscarinic receptors, nicotinic receptors, 2-Noradrenaline, Norepinephrine, Catecholamines, sympathetic depressants

Topics: Pharmacokinetics, Pharmacodynamics, Life Cycle of a Drug, Slow Absorption, Faster Absorption, Bioavailability, Depot Binding, Degradation, Excretion, Drug Effectiveness, Dose-response curve, Therapeutic Index, Effective dose, Lethal dose, Effective concentration, Drug Efficacy, Drug potency, Drug-drug Interactions, Cumulative Effects, Additive Effects, Synergistic Effects, Antagonistic Effects, Agonism, Antagonism, drug-receptor interaction

Topics: Ethics, communication, Clinical pharmacology, Environmental medicine, global health, poisoning, Palliative medicine, symptom control, Molecular cell biology, human genetics, Pharmacokinetics, Pharmacodynamics, Monitoring drug therapy, Adverse drug reactions, Drug interactions, Evidence-based medicine, maternal health, child health, accidents, trauma, conflict, catastrophe, heat injury, cold injury, drowning, air pollution, ionizing radiation, electric shock, lightning strike, smoke, noise, bioterrorism, biowarfare, Cell biology, cell structure, cell, cellular mechanisms, stem cells, human genetic analysis, chromosome, genetic disorders, population genetics, clinical genetics, genetic counselling, genomic medicine, immune system.Innate immune system, Adaptive immune system, Cell migration, HLA molecules, antigen presentation, human major histocompatibility complex, Clinical immunodeficiency, immediate hypersensitivity, allergic disease, Autoimmune disease, Organ rejection, clinical transplantation, Immune-based therapies, Water, electrolytes, Hyponatraemia, Hypernatraemia, Hypokalaemia, Hyperkalaemia, Hypomagnesaemia, Hypermagnesaemia, Hypophosphataemia, Hyperphosphataemia, Acid–base disorders, Water balance, electrolyte balance, Dietary requirements, Protein–energy malnutrition, vitamins, Fat-soluble vitamins, Water-soluble vitamins, Dietary antioxidants, Homocysteine, cardiovascular disease, B vitamins, Nutrition, Ageing, Nutritional support, obesity, Food allergy, food intolerance, alcohol, Clinical practice, Infectious diseases, tropical medicine, Sexually transmitted infections, human immunodeficiency virus, Gastrointestinal disease, Liver disease, Biliary tract disease, pancreatic disease, Haematological disease, Malignant disease, Rheumatic disease, Kidney disease, urinary tract disease, Neurological disease, Psychological medicine, Cardiovascular disease, Respiratory disease, Critical care medicine, Endocrine disease, Lipid disorder, metabolic disorder, Women's health, Skin disease, Ear disease, nose disease, throat disease, eye disease

Topics: Autonomic Pharmacology, autonomic drugs, Cholinoceptor-Activating Drug, Cholinesterase-Inhibiting Drug, Cholinoceptor-Blocking Drugs, Adrenoceptor Agonists Drug, Sympathomimetic Drug, Adrenoceptor Antagonist Drug, cardiovascular-renal drug, Antihypertensive Agents, Vasodilators, Treatment of Angina Pectoris, Heart Failure, Cardiac Arrhythmias, Diuretic Agents, actionson smooth muscle, central nervous system, inflammation, gout, endocrine drugs, chemotherapeutic drugs, toxicology, Heavy Metal Intoxication, Chelators, Poisoned Patient, Beta-Lactam, Cell Wall Antibiotics, Membrane-Active Antibiotics, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, Oxazolidinones, Aminoglycosides, Spectinomycin, Sulfonamides, Trimethoprim, Quinolones, Antimycobacterial Drugs, Antifungal Agents, antiviral agents, Antimicrobial Agents, Disinfectants, Antiseptics, Sterilants, Antimicrobial Agents, Antiprotozoal Drugs, Antihelminthic Drugs, Cancer Chemotherapy, Immunopharmacology, Hypothalamic Hormones, Pituitary Hormones, Thyroid drugs

Topics: ACUTE HAEMOLYTIC REACTION, IMMUNE MEDIATED PLATELET DESTRUCTION, FEBRILE NON-HAEMOLYTIC TRANSFUSION REACTIONS, ALLERGIC TRANSFUSION REACTIONS, ANAPHYLACTOID, ANAPHYLACTIC REACTION, TRANSFUSION RELATED ACUTE LUNG INJURY, delayed haemolytic reactions, Allo-immunization, post transfusion purpura, Transfusion associated graft vs host disease, transfusion associated immunomodulation, hypothermia, hypotension, transfusion associated cardiac overload, Circulatory Overload, iron overload, Citrate Toxicity, electrolyte imbalance, acid-base imbalance, bleeding tendency, embolism, transfusion transmissible infections, human immunodeficiency virus, cytomegalovirus, transfusion reactions

Topics: antibiotic, antimicrobial drugs, Chemotherapeutic drug resistance, Antimicrobial drug Selection, Antimicrobial drug Selection, Antimicrobial drug treatment, Antimicrobial Therapy

Topics: Oral administration, Oral drug formulations, Enteric coating, Rectal administration, Intravenous administration, Subcutaneous administration, Intramuscular administration, INJECTION TECHNIQUES, DRUG ELUTING STENTS, DRUG TRAGETING, DRUG NANOTECHNOLOGY

Topics: Therapeutics, drug action, drug absorption, drug distribution, Pharmacokinetics, Drug Metabolism, toxicology, Pharmaceutical Research, AUTONOMIC NERVOUS SYSTEM, Adrenomimetic Drugs, Adrenoceptor Antagonists, Cholinomimetics, Muscarinic Blocking Drugs, Ganglionic Blocking Drugs, Nicotine, Chronic Heart Failure, Antiarrhythmic Drugs, Antianginal Drugs, Renin–Angiotensin–Aldosterone System, Calcium Channel Blockers, Antihypertensive Drugs, Diuretic Drugs, Anticoagulant, Antiplatelet, Fibrinolytic Drugs, Thrombolytic Drugs, Hypocholesterolemic Drugs, Coronary Heart Disease, Central Nervous System Pharmacology, General Anesthesia, Intravenous Agents, Inhalational Agents, Opioid Analgesics, Nonopioid Analgesics, Local Anesthetics, Central Nervous System Stimulants, Sedative–Hypnotic Drugs, Anxiolytic Drugs, Neurodegenerative Disorders, Antiepileptic Drugs, Mood Disorder, Antipsychotic Drugs, Contemporary Drug Abuse, Antiinflammatory Drugs, Antirheumatic Drugs, Histamine, Histamine Antagonists, Gastrointestinal Disorder, asthma, Dermatological Disorder, Supragingival Plaque, Chemotherapy, Synthetic Organic Antimicrobials, Sulfonamides, Trimethoprim, Nitrofurans, Quinolones, Methenamine, Aminoglycoside Antibiotics, Tetracyclines, Chloramphenicol, Macrolides, Lincosamides, Bacitracin, Glycopeptide Antibiotics, Polymyxins, Tuberculosis, Leprosy, Antiviral Drugs, Human Immunodeficiency Virus, Antifungal Drugs, Antiprotozoal Drugs, Anthelmintic Drugs, Antineoplastic Agents, Immunomodulating Drugs, Gene Therapy, Hypothalamic Hormones, Pituitary Gland Hormones, Adrenocortical Hormones, Adrenal Cortex, Estrogens, Progestins, Uterine Stimulants, Uterine Relaxants, Androgens, Antiandrogens, Anabolic Steroids, Erectile Dysfunction, Thyroid Drugs, Antithyroid Drugs, Parathyroid Hormone, Calcitonin, Vitamin D, Mineral Metabolism, Insulin, Diabetes Mellitus, Vitamins, Herbal Medicine

Topics: PLANT-DRUG DISCOVERY, Drug Discovery Process, Genomics, proteomics, Current therapy, Assay Development, Hit Validation, Lead Compound, Lead Optimisation, Preclinical Evaluation, Preclinical toxicity studies, In vivo tests, Test validity, Multiple Ascending Dose, drug Development

Topics: Clinical Biochemistry, clinical Pharmacology, Renal Function Tests, renal clearance, Creatinine Clearance Test, Urea Clearance Test, insulin clearance, Drug Metabolism, drug design, drug testing, Serendipity, Rational drug design

Topics: pharmacovigilance

Topics: Pharmacotherapeutics, Pharmacokinetics, Pharmacogenomics, Pharmacological effect, Therapeutic index, Therapeutic Range, Steady state, pharmacokinetic studies, Therapeutic drug monitoring testing, Minimum Effective Concentration, Maximum Therapeutic Concentration, Minimum Toxic Concentration, Half Life of a drug, First order kinetics, Zero order kinetics, Michaelis-Menten kinetics, Kinetic homogeneity, Antiepileptics, Antimanics, Antineoplastics, Bronchodilators, Chromatographic techniques, Thin layer chromatography, High performance liquid chromatography, Gas chromatography–mass spectroscopy, Therapeutic Range, Antiarrythmics, Antibiotics, Immunosuppressives